Article
Novel platelet membrane glycoprotein VI dimorphism is a risk factor for myocardial infarction.
Circulation - 25 Sept 2001
Croft S A, Samani N J, Teare M D, Hampton K K, Steeds R P, Channer K S, Daly M E
Abstract excerpt
BACKGROUND: Glycoprotein (GP) VI plays a crucial role in platelet activation and aggregation. We investigated whether polymorphic variation at the GP VI locus confers an increased risk of myocardial infarction (MI). METHODS AND RESULTS: Coding and 5' and 3' non-coding regions of the GP VI gene were analyzed by polymerase chain reaction and conformation sensitive gel electrophoresis in 21 healthy subjects. Ten...
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