V79 Chinese hamster lung cells resistant to the bis-alkylator bizelesin are multidrug-resistant.

doi:10.1007/BF00686110

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Article

V79 Chinese hamster lung cells resistant to the bis-alkylator bizelesin are multidrug-resistant.

Cancer chemotherapy and pharmacology - 1 Jan 1994

Butryn R K, Smith K S, Adams E G, Abraham I, Stackpole J, Sampson K E, Bhuyan B K

Abstract excerpt

Bizelesin (U-77779) is a highly potent bis-alkylating antitumor agent that is effective against several tumor systems in vitro and in vivo. V79 cells that were 125- to 250-fold resistant to bizelesin developed after constant exposure to gradually increasing concentrations of the drug. Resistant cells exhibited a multidrug-resistant phenotype and genotype as indicated by cross-resistant to several structurally and...

Topics

Alkylating Agents
Animals
Antineoplastic Agents
Blotting, Northern
Cell Division
Cell Line
Cell Survival
Cricetinae
Cricetulus
Drug Resistance
Duocarmycins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fibroblasts

Genotype

Humans

Indoles

Lung

Mice

Phenotype

Source

Open in PubMed

Identifiers

PMID: 7513620
DOI: 10.1007/BF00686110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7513620-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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