Article
Genetic variations in the ATP-binding cassette transporter ABCC10 are associated with neutropenia in Japanese patients with lung cancer treated with nanoparticle albumin-bound paclitaxel.
Investigational new drugs - 1 Oct 2022
Horiuchi Minoru, Uemura Takehiro, Oguri Tetsuya, Toda Sanae, Yamamoto Sayaka, Suzuki Yuto, Kagawa Yusuke, Sone Kazuki, Fukuda Satoshi, Mori Yuta, Fukumitsu Kensuke, Kanemitsu Yoshihiro, Tajiri Tomoko, Ohkubo Hirotsugu, Takemura Masaya, Ito Yutaka, Maeno Ken, Niimi Akio
Abstract excerpt
ABCC10/MRP7, an ATP-binding cassette (ABC) transporter, has been implicated in the extracellular transport of taxanes. Our group reported that the ABCC10 single nucleotide polymorphism (SNPs), rs2125739, influences docetaxel cytotoxicity in lung cancer cell lines as well as its side effects in clinical practice. In this study, we investigated whether the rs2125739 variant could affect paclitaxel (PTX)...
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