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Human drug efflux transporter ABCC5 confers acquired resistance to pemetrexed in breast cancer

25 Feb 2021

Abstract excerpt

Abstract Aim Pemetrexed, a new generation antifolate drug, has been approved for the treatment of locally advanced or metastatic breast cancer. However, factors affecting its efficacy and resistance have not been fully elucidated yet. ATP-binding cassette (ABC) transporters are predictors of prognosis as well as of adverse effects of several xenobiotics. This study was designed to explore whether ABC transporters...

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PMID: 33632224
DOI: 10.1186/s12935-021-01842-x

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