Downregulated ABCG2 enhances sensitivity to topoisomerase I inhibitor in epidermal growth factor receptor tyrosine kinase inhibitor-resistant non-small cell lung cancer.

doi:10.1097/JTO.0b013e3181f0b6af

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Article

Downregulated ABCG2 enhances sensitivity to topoisomerase I inhibitor in epidermal growth factor receptor tyrosine kinase inhibitor-resistant non-small cell lung cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Nov 2010

Ohtsuka Kouki, Ohnishi Hiroaki, Morii Takeshi, Fujiwara Masachika, Kishino Tomonori, Ogura Wataru, Chiba Misaki, Matsushima Satsuki, Goya Tomoyuki, Watanabe Takashi

Abstract excerpt

INTRODUCTION: Understanding the mechanisms of drug resistance to epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) is essential to develop novel chemotherapies for non-small cell lung cancer (NSCLC). Therefore, we analyzed the expression and function of ATP-binding cassette (ABC) transporters in EGFR TKI-resistant NSCLC. METHODS: In three newly established AG1478-resistant NSCLC cell lines, we...

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PMID: 20975373
DOI: 10.1097/JTO.0b013e3181f0b6af

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ABCG2
EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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