Article

Human Drug Efflux Transporter ABCC5 Confers Acquired Resistance to Pemetrexed in Breast Cancer

2021-01-27

Abstract excerpt

<title>Abstract</title> <p><bold>Aim</bold>Pemetrexed, a new generation antifolate drug, is approved for the treatment for locally advanced or metastatic breast cancer, but factors affecting the efficacy and resistance of it have yet to be fully explicit. ATP-binding cassette (ABC) transporters have been reported as prognostic and adverse effects predictors of many xenobiotics. This study was designed to explore...

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Literature Corpus work: ef7517c2-707b-5042-b85e-fe5391991033
DOI: 10.21203/rs.3.rs-105352/v2

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