Beta-catenin mutation in carcinoma of the uterine endometrium.

Article

Beta-catenin mutation in carcinoma of the uterine endometrium.

Cancer research - 15 Aug 1998

Fukuchi T, Sakamoto M, Tsuda H, Maruyama K, Nozawa S, Hirohashi S

Abstract excerpt

Beta-catenin forms complexes with Tcf and Lef-1 and functions as a transcriptional activator downstream of the Wnt signaling pathway. Activation of the pathway by stabilization of beta-catenin has been shown to be important in the development of colorectal carcinoma, which is mainly caused by ina...

Topics

Adult
Aged
Carcinoma
Cytoskeletal Proteins
DNA Mutational Analysis
Endometrial Neoplasms
Female
Humans
Loss of Heterozygosity
Middle Aged
Mutation
Neoplasm Proteins
Trans-Activators
beta Catenin

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