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Article

Beta-catenin mutation in carcinoma of the uterine endometrium.

Cancer research - 15 Aug 1998

Fukuchi T, Sakamoto M, Tsuda H, Maruyama K, Nozawa S, Hirohashi S

Abstract excerpt

Beta-catenin forms complexes with Tcf and Lef-1 and functions as a transcriptional activator downstream of the Wnt signaling pathway. Activation of the pathway by stabilization of beta-catenin has been shown to be important in the development of colorectal carcinoma, which is mainly caused by inactivating mutations of the adenomatous polyposis coli tumor suppressor gene or by activating mutations in exon 3 of the...

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PMID: 9721853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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