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Article

PECAM-1 protects against DIC by dampening inflammatory responses via inhibiting macrophage pyroptosis and restoring vascular barrier integrity.

Translational research : the journal of laboratory and clinical medicine - 1 Aug 2020

Luo Lili, Xu Min, Liao Danying, Deng Jun, Mei Heng, Hu Yu

Abstract excerpt

Disseminated intravascular coagulation (DIC) is a frequent complication of sepsis that affects patient outcomes due to accompanying thrombo-inflammation and microvascular permeability changes. Platelet endothelial cell adhesion molecule-1 (PECAM-1), a cellular adhesion and signaling receptor that is expressed on both hematopoietic and endothelial cells, plays an important anti-inflammatory role in acute and...

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Identifiers

PMID: 32417429
DOI: 10.1016/j.trsl.2020.04.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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