Epigenetic and phenotypic consequences of a truncation disrupting the imprinted domain on distal mouse chromosome 7.

doi:10.1128/MCB.01019-07

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Epigenetic and phenotypic consequences of a truncation disrupting the imprinted domain on distal mouse chromosome 7.

Molecular and cellular biology - 1 Feb 2008

Oh Rosemary, Ho Rita, Mar Lynn, Gertsenstein Marina, Paderova Jana, Hsien John, Squire Jeremy A, Higgins Michael J, Nagy Andras, Lefebvre Louis

Abstract excerpt

The distal end of mouse chromosome 7 (Chr 7) contains a large cluster of imprinted genes. In this region two cis-acting imprinting centers, IC1 (H19 DMR) and IC2 (KvDMR1), define proximal and distal subdomains, respectively. To assess the functional independence of IC1 in the context of Chr 7, we developed a recombinase-mediated chromosome truncation strategy in embryonic stem cells and generated a terminal...

Topics

Alleles
Animals
Chromosomes, Mammalian
DNA Methylation
Embryonic Stem Cells
Epigenesis, Genetic
Genomic Imprinting
Heterozygote
Mice
Phenotype
Sequence Deletion

Source

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 18039841
DOI: 10.1128/MCB.01019-07
PMCID: PMC2223404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.