Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic and phenotypic consequences of a truncation disrupting the imprinted domain on distal mouse chromosome 7.

Molecular and cellular biology - 1 Feb 2008

Oh Rosemary, Ho Rita, Mar Lynn, Gertsenstein Marina, Paderova Jana, Hsien John, Squire Jeremy A, Higgins Michael J, Nagy Andras, Lefebvre Louis

Abstract excerpt

The distal end of mouse chromosome 7 (Chr 7) contains a large cluster of imprinted genes. In this region two cis-acting imprinting centers, IC1 (H19 DMR) and IC2 (KvDMR1), define proximal and distal subdomains, respectively. To assess the functional independence of IC1 in the context of Chr 7, we developed a recombinase-mediated chromosome truncation strategy in embryonic stem cells and generated a terminal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Mammalian
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Embryonic Stem Cells

Share to Epigenesis, Genetic

Share to Genomic Imprinting

Share to Heterozygote

Share to Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 18039841
DOI: 10.1128/MCB.01019-07
PMCID: PMC2223404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic and phenotypic consequences of a truncation disrupting the imprinted domain on distal mouse chromosome 7.PMID 18039841Read ↗

Multiple Mechanisms Regulate Imprinting of the Mouse Distal Chromosome 7 Gene ClusterSemantic proximity Read ↗

The two-domain hypothesis in Beckwith–Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 clusterSemantic proximity Read ↗

A genomic imprinting defect in mice traced to a single gene.Semantic proximity Read ↗

Embryological and molecular investigations of parental imprinting on mouse chromosome 7Semantic proximity Read ↗

G9a Histone Methyltransferase Contributes to Imprinting in the Mouse PlacentaSemantic proximity Read ↗

Microarray expression profiling of tissues from mice with uniparental duplications of chromosomes 7 and 11 to identify imprinted genes.Semantic proximity Read ↗

Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexesSemantic proximity Read ↗

Spatially restricted imprinting of mouse chromosome 7.Semantic proximity Read ↗

Differentially methylated regions in maternal and paternal uniparental disomy for chromosome 7.Semantic proximity Read ↗

Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylationSemantic proximity Read ↗

Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene.Semantic proximity Read ↗

Mosaic analysis with double markers reveals cell-type-specific paternal growth dominance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.