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Article

Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation.

Disease models & mechanisms - 1 Jan 2000

Ishizaki Hironori, Spitzer Michaela, Wildenhain Jan, Anastasaki Corina, Zeng Zhiqiang, Dolma Sonam, Shaw Michael, Madsen Erik, Gitlin Jonathan, Marais Richard, Tyers Mike, Patton E Elizabeth

Abstract excerpt

Hypopigmentation is a feature of copper deficiency in humans, as caused by mutation of the copper (Cu(2+)) transporter ATP7A in Menkes disease, or an inability to absorb copper after gastric surgery. However, many causes of copper deficiency are unknown, and genetic polymorphisms might underlie sensitivity to suboptimal environmental copper conditions. Here, we combined phenotypic screens in zebrafish for...

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Identifiers

PMID: 20713646
DOI: 10.1242/dmm.005769
PMCID: PMC2938393

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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