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Article

Atp7b deficiency induces zebrafish eye developmental defects.

Metallomics : integrated biometal science - 2 May 2023

Wu You, Liu Wenye, Li Lingya, Tai Zhipeng, Gao BaoXiang, Liu Jing-Xia

Abstract excerpt

As a copper (Cu) transport ATPase, ATP7B plays an important role in maintaining Cu homeostasis in the body and its dysfunction is associated with retinal disease. How ATP7B dysfunction and the subsequent Cu overload induce retinal damage, however, are unknown. Here, we show that atp7b-/- homozygous zebrafish larvae are insensitive to light stimulation, with a reduction in retinal cells but normal like...

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PMID: 37070960
DOI: 10.1093/mtomcs/mfad024

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