Article
Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms.
Genes & development - 15 Aug 2010
Zhang Yuzhen, Li Shanru, Yuan Lijun, Tian Ying, Weidenfeld Joel, Yang Jifu, Liu Feiyan, Chokas Ann L, Morrisey Edward E
Abstract excerpt
Cardiomyocyte proliferation is high in early development and decreases progressively with gestation, resulting in the lack of a robust cardiomyocyte proliferative response in the adult heart after injury. Little is understood about how both cell-autonomous and nonautonomous signals are integrated to regulate the balance of cardiomyocyte proliferation during development. In this study, we show that a single...
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