Article
HLA-DQA, -DQB and -DRB allele contribution to narcolepsy susceptibility.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Dec 1997
Planelles D, Puig N, Beneto A, Gomez E, Rubio P, Mirabet V, Bonanad S, Blasco I, Montoro J A
Abstract excerpt
The association of narcolepsy with HLA class I antigens and HLA class II alleles was studies in a series of Spanish narcoleptic patients. The haplotype DRB1*1501-DRB5*0101-DQA1*0102-DQB1*0602 was found to be significantly associated with the disease, while the haplotype DRB1*0701-DRB4*01-DQA1*020...
Topics
- Adolescent
- Adult
- Alleles
- Child
- Female
- Genes, MHC Class II
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DR Antigens
- Haplotypes
- Histocompatibility Antigens Class I
- Histocompatibility Testing
- Homozygote
- Humans
- Linkage Disequilibrium
- Male
- Narcolepsy
- Predictive Value of Tests