Article
Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2001
De Windt L J, Lim H W, Bueno O F, Liang Q, Delling U, Braz J C, Glascock B J, Kimball T F, del Monte F, Hajjar R J, Molkentin J D
Abstract excerpt
The Ca(2+)-calmodulin-activated Ser/Thr protein phosphatase calcineurin and the downstream transcriptional effectors of calcineurin, nuclear factor of activated T cells, have been implicated in the hypertrophic response of the myocardium. Recently, the calcineurin inhibitory agents cyclosporine A and FK506 have been extensively used to evaluate the importance of this signaling pathway in rodent models of cardiac...
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