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Article

The cytosolic phospholipase A2 catalytic domain modulates association and residence time at Golgi membranes.

The Journal of biological chemistry - 13 Feb 2004

Evans John H, Leslie Christina C

Abstract excerpt

Cytosolic phospholipase A2 (cPLA2) catalyzes release of arachidonic acid from membranes following translocation to Golgi and endoplasmic reticulum. In response to an intracellular calcium concentration ([Ca2+]i) increase, the C2 domain binds Ca2+ and brings the catalytic domain into proximity with its phospholipid substrate. Because membrane residence is important in the regulation of cPLA2 activity, we explored...

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Identifiers

PMID: 14623879
DOI: 10.1074/jbc.M311246200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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