Article
Impact of accumulated alterations in driver and passenger genes on response to radiation therapy.
The British journal of radiology - 1 May 2020
Seo Yuji, Tamari Keisuke, Takahashi Yutaka, Minami Kazumasa, Isohashi Fumiaki, Suzuki Osamu, Sumida Iori, Ogawa Kazuhiko
Abstract excerpt
OBJECTIVE: Although various single genetic factors have been shown to affect radiosensitivity, high-throughput DNA sequencing analyses have revealed complex genomic landscapes in many cancer types. The aim of this study is to elucidate the association between accumulated alterations in driver and passenger genes and radiation therapy response. METHODS: We used 59 human solid cancer cell lines derived from 11...
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