Article
Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype.
Nature reviews. Cancer - 1 Feb 2009
Barnett Gillian C, West Catherine M L, Dunning Alison M, Elliott Rebecca M, Coles Charlotte E, Pharoah Paul D P, Burnet Neil G
Abstract excerpt
A key challenge in radiotherapy is to maximize radiation doses to cancer cells while minimizing damage to surrounding healthy tissue. As severe toxicity in a minority of patients limits the doses that can be safely given to the majority, there is interest in developing a test to measure an individual's radiosensitivity before treatment. Variation in sensitivity to radiation is an inherited genetic trait and...
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