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Structural and mechanistic insight into how antibodies inhibit serine proteases

13 Aug 2010

Abstract excerpt

Antibodies display great versatility in protein interactions and have become important therapeutic agents for a variety of human diseases. Their ability to discriminate between highly conserved sequences could be of great use for therapeutic approaches that target proteases, for which structural features are conserved among family members. Recent crystal structures of antibody-protease complexes provide exciting...

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PMID: 20704569
DOI: 10.1042/bj20100634

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