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Article

Molecular basis for the mechanism of action of an anti-TACE antibody

9 Sept 2016

Abstract excerpt

Inhibitors of tumor necrosis factor-α converting enzyme (TACE) have potential as therapeutics for various diseases. Many small molecule inhibitors, however, exhibit poor specificity profiles because they target the highly conserved catalytic cleft of TACE. We report for the first time the molecular interaction of a highly specific anti-TACE antagonistic antibody (MEDI3622). We characterized the binding of...

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PMID: 27610476
DOI: 10.1080/19420862.2016.1226716

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