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Article

A unique preovulatory expression pattern plays a key role in the physiological functions of BMP-15 in the mouse.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jul 2006

Yoshino Osamu, McMahon Heather E, Sharma Shweta, Shimasaki Shunichi

Abstract excerpt

Mutations in the bone morphogenetic protein 15 (BMP-15) gene cause female infertility in the monoovulatory human and sheep; however, in the polyovulatory mouse, loss-of-function of BMP-15 results only in reduced ovulation rate. To elucidate the cause of these species-specific differences, we investigated the functional role of BMP-15 in the mouse ovary. Here, we found that the functional mature form of BMP-15 is...

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Share to Bone Morphogenetic Protein 15
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Growth Differentiation Factor 9

Share to Intercellular Signaling Peptides and Proteins

Share to Oocytes

Share to Ovulation

Share to Species Specificity

Source

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Identifiers

PMID: 16818886
DOI: 10.1073/pnas.0600507103
PMCID: PMC1502291

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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