Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Nov 2008

Kawahara Yukio, Grimberg Adda, Teegarden Sarah, Mombereau Cedric, Liu Sui, Bale Tracy L, Blendy Julie A, Nishikura Kazuko

Abstract excerpt

RNA editing that converts adenosine to inosine replaces the gene-encoded Ile, Asn, and Ile (INI) of serotonin [5-hydroxytryptamine (5-HT)] receptor 2C (5-HT(2C)R) with Val, Gly, and Val (VGV). Up to 24 different 5-HT(2C)R isoforms are detected in different brain regions (Burns et al., 1997; Fitzgerald et al., 1999; Wang et al., 2000). To elucidate the physiological significance of 5-HT(2C)R mRNA editing, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Gene Knock-In Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptor, Melanocortin, Type 4

Share to Receptor, Serotonin, 5-HT2C

Share to RNA Editing

Share to Serotonin

Share to Sympathetic Nervous System

Share to Synaptic Transmission

Source

Open in PubMed Open full text

Identifiers

PMID: 19036977
DOI: 10.1523/JNEUROSCI.3896-08.2008
PMCID: PMC2615198

Genes

MC4R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass.PMID 19036977Read ↗

Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndrome.Semantic proximity Read ↗

RNA splicing and editing modulation of 5-HT(2C) receptor function: relevance to anxiety and aggression in VGV mice.Semantic proximity Read ↗

A-to-I editing of the 5HT2C receptor and behaviourSemantic proximity Read ↗

Functional relevance of serotonin 2C receptor mRNA editing in antidepressant- and anxiety-like behaviorsSemantic proximity Read ↗

A-to-I pre-mRNA editing of the serotonin 2C receptor: comparisons among inbred mouse strains.Semantic proximity Read ↗

Mouse models for V103I and I251L gain of function variants of the human MC4R display reduced adiposity and are not protected from a hypercaloric dietSemantic proximity Read ↗

Serotonin receptor 2C and mental disorders: genetic, expression and RNA editing studies.Semantic proximity Read ↗

An innovative real-time PCR method to measure changes in RNA editing of the serotonin 2C receptor (5-HT(2C)R) in brain.Semantic proximity Read ↗

No link of serotonin 2C receptor editing to serotonin transporter genotype.Semantic proximity Read ↗

RNA Editing of the Human Serotonin 5-HT2C Receptor Alterations in Suicide and Implications for Serotonergic PharmacotherapySemantic proximity Read ↗

Constitutive activity of serotonin 2C receptors at G protein-independent signaling: modulation by RNA editing and antidepressants.Semantic proximity Read ↗

RNA editing of serotonin 2C receptor in human postmortem brains of major mental disordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.