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Deregulation of E-cadherin by human papillomavirus is not confined to high-risk, cancer-causing types

2 Aug 2010

Abstract excerpt

BACKGROUND: E-cadherin is a tumour suppressor protein, which is normally expressed on keratinocytes and antigen-presenting Langerhans cells (LCs) in the epidermis. We have previously shown that E-cadherin is lost from tissues infected with the high-risk cancer-causing human papillomavirus (HPV) type 16. OBJECTIVES: To test if E-cadherin dysregulation is associated with the cancer risk of the infecting HPV and to...

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PMID: 20698848
DOI: 10.1111/j.1365-2133.2010.09968.x

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