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Small-molecule inducers of insulin expression in pancreatic α-cells

9 Aug 2010

Abstract excerpt

High-content screening for small-molecule inducers of insulin expression identified the compound BRD7389, which caused alpha-cells to adopt several morphological and gene expression features of a beta-cell state. Assay-performance profile analysis suggests kinase inhibition as a mechanism of action, and we show that biochemical and cellular inhibition of the RSK kinase family by BRD7389 is likely related to its...

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PMID: 20696901
DOI: 10.1073/pnas.1010018107

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