Article

Select DYRK1A Inhibitors Enhance Both Proliferation and Differentiation in Human Pancreatic Beta Cells

2024-05-17

Abstract excerpt

The small molecule DYRK1A inhibitor, harmine, induces human beta cell proliferation, expands beta cell mass, enhances expression of beta cell phenotypic genes, and improves human beta cell function i n vitro and in vivo . It is unknown whether the “pro-differentiation effect” is a DYRK1A inhibitor class-wide effect. Here we compare multiple commonly studied DYRK1A inhibitors. Harmine, 2-2c and 5-IT increase expr...

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Literature Corpus work: 3b24aa30-2511-5554-8e9f-08a1dc1d3930
DOI: 10.1101/2024.05.17.594179

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