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Article

AdeIJK, a Resistance-Nodulation-Cell Division Pump Effluxing Multiple Antibiotics in <i>Acinetobacter baumannii</i>

18 Dec 2007

Abstract excerpt

We have identified a second resistance-nodulation-cell division (RND)-type efflux pump, AdeIJK, in clinical isolate Acinetobacter baumannii BM4454. The adeI, adeJ, and adeK genes encode, respectively, the membrane fusion, RND, and outer membrane components of the pump. AdeJ belongs to the AcrB protein family (57% identity with AcrB from Escherichia coli). mRNA analysis by Northern blotting and reverse...

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Identifiers

PMID: 18086852
DOI: 10.1128/aac.00732-07

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AdeIJK, a Resistance-Nodulation-Cell Division Pump Effluxing Multiple Antibiotics in <i>Acinetobacter baumannii</i>PMID 18086852Read ↗

Overexpression of Resistance-Nodulation-Cell Division Pump AdeFGH Confers Multidrug Resistance in <i>Acinetobacter baumannii</i>Semantic proximity Read ↗

RND pumps across the genus Acinetobacter: AdeIJK is the universal efflux pumpSemantic proximity Read ↗

RND pumps across the <i>Acinetobacter</i> genus; AdeIJK is the ancestral efflux systemSemantic proximity Read ↗

Inactivation of AdeABC and AdeIJK efflux pumps elicits specific nonoverlapping transcriptional and phenotypic responses in Acinetobacter baumannii.Semantic proximity Read ↗

RND-type efflux pumps in multidrug-resistant clinical isolates of Acinetobacter baumannii: major role for AdeABC overexpression and AdeRS mutations.Semantic proximity Read ↗

Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454.Semantic proximity Read ↗

Expression of the resistance-nodulation-cell division pump AdeIJK in Acinetobacter baumannii is regulated by AdeN, a TetR-type regulator.Semantic proximity Read ↗

Characteristics and Diversity of Mutations in Regulatory Genes of Resistance-nodulation-cell Division Efflux Pumps in Association With Drug-resistant Clinical Isolates of Acinetobacter BaumanniiSemantic proximity Read ↗

Contribution of RND superfamily multidrug efflux pumps AdeABC, AdeFGH, and AdeIJK to antimicrobial resistance and virulence factors in multidrug-resistant Acinetobacter baumannii AYESemantic proximity Read ↗

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Tigecycline Efflux as a Mechanism for Nonsusceptibility in <i>Acinetobacter baumannii</i>Semantic proximity Read ↗

Distribution and expression of the Ade multidrug efflux systems in Acinetobacter baumannii clinical isolatesSemantic proximity Read ↗

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