Article
Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket.
Molecular microbiology - 1 Mar 2009
Long Katherine S, Poehlsgaard Jacob, Hansen Lykke H, Hobbie Sven N, Böttger Erik C, Vester Birte
Abstract excerpt
Tiamulin and valnemulin target the peptidyl transferase centre (PTC) on the bacterial ribosome. They are used in veterinary medicine to treat infections caused by a variety of bacterial pathogens, including the intestinal spirochetes Brachyspira spp. Mutations in ribosomal protein L3 and 23S rRNA...
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