Article
SRF binding to SRE 6.9 in the Arc promoter is essential for LTD in cultured Purkinje cells.
Nature neuroscience - 1 Sept 2010
Smith-Hicks Constance, Xiao Bo, Deng Rongkang, Ji Yifei, Zhao Xia, Shepherd Jason D, Posern Guido, Kuhl Dietmar, Huganir Richard L, Ginty David D, Worley Paul F, Linden David J
Abstract excerpt
It has been suggested that gene expression and protein synthesis are required for both long-term memory consolidation and late phases of long-term potentiation and long-term depression (LTD). The necessary genes and the specific transcription factor binding sites in their promoters remain unknown. We found that inhibition of the transcription factor SRF or its cofactor MAL blocked the late phase of LTD in mouse...
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