Article
ERG rearrangement is present in a subset of transition zone prostatic tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2010
Falzarano Sara M, Navas Maria, Simmerman Kelly, Klein Eric A, Rubin Mark A, Zhou Ming, Magi-Galluzzi Cristina
Abstract excerpt
A majority of prostate cancers exhibit a recurrent gene rearrangement involving chromosome 21. In approximately 90% of cases, the rearrangement is characterized by fusion of the androgen-regulated gene TMPRSS2 with the oncogene ERG. A recent study suggested that TMPRSS2-ERG gene fusion is lacking in cancers arising from the transition zone of the prostate. A dominant transition zone cancer was detected in 62/397...
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