Article
Morphological features of TMPRSS2-ERG gene fusion prostate cancer.
The Journal of pathology - 1 May 2007
Mosquera J-M, Perner S, Demichelis F, Kim R, Hofer M D, Mertz K D, Paris P L, Simko J, Collins C, Bismar T A, Chinnaiyan A M, Rubin M A
Abstract excerpt
The TMPRSS2-ETS fusion prostate cancers comprise 50-70% of the prostate-specific antigen (PSA)-screened hospital-based prostate cancers examined to date, making it perhaps the most common genetic rearrangement in human cancer. The most common variant involves androgen-regulated TMPRSS2 and ERG, both located on chromosome 21. Emerging data from our group and others suggests that TMPRSS2-ERG fusion prostate cancer...
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