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Article

Block of neuronal Na+ channels by antidepressant duloxetine in a state-dependent manner.

Anesthesiology - 1 Sept 2010

Wang Sho-Ya, Calderon Joanna, Kuo Wang Ging

Abstract excerpt

BACKGROUND: Duloxetine is a mixed serotonin-norepinephrine reuptake inhibitor used for major depressive disorder. Duloxetine is also beneficial for patients with diabetic peripheral neuropathy and with fibromyalgia, but how it works remains unclear. METHODS: We used the whole cell, patch clamp technique to test whether duloxetine interacts with the neuronal Nav1.7 Na+ channel as a potential target. Resting and...

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Identifiers

PMID: 20693878
DOI: 10.1097/ALN.0b013e3181e89a93

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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