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Article

Variants in the SIRT1 gene may affect diabetes risk in interaction with prenatal exposure to famine.

Diabetes care - 1 Feb 2012

Botden Ilse P G, Zillikens M Carola, de Rooij Susanne R, Langendonk Janneke G, Danser A H Jan, Sijbrands Eric J G, Roseboom Tessa J

Abstract excerpt

OBJECTIVE: To investigate whether SIRT1, a nutrient-sensing histone deacetylase, influences fetal programming during malnutrition. RESEARCH DESIGN AND METHODS: In 793 individuals of the Dutch Famine Birth Cohort, we analyzed the interaction between three SIRT1 single nucleotide polymorphisms (SNPs) and prenatal exposure to famine on type 2 diabetes risk. RESULTS: In the total population (exposed and unexposed),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22228742
DOI: 10.2337/dc11-1203
PMCID: PMC3263901

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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