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Article

Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams-Beuren syndrome.

eLife - 11 Oct 2022

Navarro-Romero Alba, Galera-López Lorena, Ortiz-Romero Paula, Llorente-Ovejero Alberto, de Los Reyes-Ramírez Lucía, Bengoetxea de Tena Iker, Garcia-Elias Anna, Mas-Stachurska Aleksandra, Reixachs-Solé Marina, Pastor Antoni, de la Torre Rafael, Maldonado Rafael, Benito Begoña, Eyras Eduardo, Rodríguez-Puertas Rafael, Campuzano Victoria, Ozaita Andres

Abstract excerpt

Williams-Beuren syndrome (WBS) is a rare genetic multisystemic disorder characterized by mild-to-moderate intellectual disability and hypersocial phenotype, while the most life-threatening features are cardiovascular abnormalities. Nowadays, there are no pharmacological treatments to directly ameliorate the main traits of WBS. The endocannabinoid system (ECS), given its relevance for both cognitive and...

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Identifiers

PMID: 36217821
DOI: 10.7554/eLife.72560
PMCID: PMC9553213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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