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Article

Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2).

Biochimica et biophysica acta - 1 Jan 2011

Edwards Noel, Anderson Catriona M H, Gatfield Kelly M, Jevons Mark P, Ganapathy Vadivel, Thwaites David T

Abstract excerpt

The H(+)-coupled amino acid transporter PAT2 (SLC36A2) transports the amino acids proline, glycine, alanine and hydroxyproline. A physiological role played by PAT2 in amino acid reabsorption in the renal proximal tubule is demonstrated by mutations in SLC36A2 that lead to an iminoglycinuric phenotype (imino acid and glycine uria) in humans. A number of proline, GABA and tryptophan derivatives were examined to...

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Identifiers

PMID: 20691150
DOI: 10.1016/j.bbamem.2010.07.032
PMCID: PMC3000476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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