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Article

T-type amino acid transporter TAT1 (Slc16a10) is essential for extracellular aromatic amino acid homeostasis control.

The Journal of physiology - 15 Dec 2012

Mariotta Luca, Ramadan Tamara, Singer Dustin, Guetg Adriano, Herzog Brigitte, Stoeger Claudia, Palacín Manuel, Lahoutte Tony, Camargo Simone M R, Verrey François

Abstract excerpt

The uniporter TAT1 (Slc16a10) mediates the facilitated diffusion of aromatic amino acids (AAAs) across basolateral membranes of kidney, small intestine and liver epithelial cells, and across the plasma membrane of non-epithelial cells like skeletal myocytes. Its role for body AA homeostasis has now been investigated using newly generated TAT1 (Slc16a10) defective mice (tat1(-/-)). These mice grow and reproduce...

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Share to Amino Acid Transport Systems, Neutral
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23045339
DOI: 10.1113/jphysiol.2012.239574
PMCID: PMC3533202

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