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Article

Defective intestinal amino acid absorption in Ace2 null mice.

American journal of physiology. Gastrointestinal and liver physiology - 15 Sept 2012

Singer Dustin, Camargo Simone M R, Ramadan Tamara, Schäfer Matthias, Mariotta Luca, Herzog Brigitte, Huggel Katja, Wolfer David, Werner Sabine, Penninger Josef M, Verrey François

Abstract excerpt

Mutations in the main intestinal and kidney luminal neutral amino acid transporter B(0)AT1 (Slc6a19) lead to Hartnup disorder, a condition that is characterized by neutral aminoaciduria and in some cases pellagra-like symptoms. These latter symptoms caused by low-niacin are thought to result from defective intestinal absorption of its precursor L-tryptophan. Since Ace2 is necessary for intestinal B(0)AT1...

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Identifiers

PMID: 22790597
DOI: 10.1152/ajpgi.00140.2012

Genes

SIT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Defective intestinal amino acid absorption in Ace2 null mice.PMID 22790597Read ↗

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