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Article

Binding of filamentous actin to anthrax toxin receptor 1 decreases its association with protective antigen.

Biochemistry - 14 Feb 2012

Garlick Kristopher M, Batty Sarah, Mogridge Jeremy

Abstract excerpt

ANTXR1 is a type I membrane protein that binds the protective antigen (PA) component of anthrax toxin. The cytosolic domain of ANTXR1 has a novel actin-binding region that influences the interaction of the ectodomain with PA. Here, we have investigated features of the cytosolic domain of ANTXR1 that reduce the association of the receptor with PA. We mutated a stretch of conserved acidic amino acids adjacent to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22303962
DOI: 10.1021/bi2016469
PMCID: PMC3286128

Genes

ANTXR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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