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Article

Association analysis of CFH, C2, BF, and HTRA1 gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathy.

Investigative ophthalmology & visual science - 1 Jun 2008

Lee Kelvin Y, Vithana Eranga N, Mathur Ranjana, Yong Victor H, Yeo Ian Y, Thalamuthu Anbupalam, Lee Mun-Wai, Koh Adrian H, Lim Marcus C, How Alicia C, Wong Doric W, Aung Tin

Abstract excerpt

PURPOSE: Polypoidal choroidal vasculopathy (PCV) is a major cause of serosanguinous maculopathy in Chinese patients with age-related macular degeneration (AMD). Variants in the CFH and HTRA1/LOC387715 genes are strongly associated with AMD in Caucasians and Chinese. Variants in the C2 and BF genes have been found to confer a significantly reduced risk of AMD. This study was undertaken to determine whether these...

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Identifiers

PMID: 18515590
DOI: 10.1167/iovs.07-0860

Genes

CFH
HTRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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