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Article

Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide.

Bioorganic & medicinal chemistry letters - 1 Sept 2010

Di Fiore Anna, Truppo Emanuela, Supuran Claudiu T, Alterio Vincenzo, Dathan Nina, Bootorabi Fatemeh, Parkkila Seppo, Monti Simona Maria, De Simone Giuseppina

Abstract excerpt

Human carbonic anhydrase VII (hCA VII) is a cytosolic member of the alpha-CA family. This enzyme is mainly localized in a number of brain tissues such as the cortex, hippocampus and thalamus and has been noted for its contribution in generating neuronal excitation and seizures. Recently, it has been also proposed that hCA VII may be involved in the control of neuropathic pain, thus its inhibition may offer a new...

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Identifiers

PMID: 20688517
DOI: 10.1016/j.bmcl.2010.07.051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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