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Mitochondrial Cascade Hypothesis of Alzheimer's Disease: Myth or Reality?

15 Sept 2007

Abstract excerpt

Mitochondria are recognized to play a pivotal role in neuronal cell survival or death because they are regulators of both energy metabolism and apoptotic pathways. Morphologic, biochemical, and molecular genetic studies suggest that mitochondria might be a convergence point for neurodegeneration, including Alzheimer's disease (AD). The functions and properties of mitochondria might render subsets of selectively...

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PMID: 17887917
DOI: 10.1089/ars.2007.1761

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