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The Alzheimer’s Disease Mitochondrial Cascade Hypothesis: A Current Overview

11 Feb 2023

Abstract excerpt

Viable Alzheimer's disease (AD) hypotheses must account for its age-dependence; commonality; association with amyloid precursor protein, tau, and apolipoprotein E biology; connection with vascular, inflammation, and insulin signaling changes; and systemic features. Mitochondria and parameters influenced by mitochondria could link these diverse characteristics. Mitochondrial biology can initiate changes in...

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PMID: 36806512
DOI: 10.3233/jad-221286

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