Article
Ranking bias in association studies.
Human heredity - 1 Jan 2009
Jeffries Neal O
Abstract excerpt
BACKGROUND: It is widely appreciated that genomewide association studies often yield overestimates of the association of a marker with disease when attention focuses upon the marker showing the strongest relationship. For example, in a case-control setting the largest (in absolute value) estimated odds ratio has been found to typically overstate the association as measured in a second, independent set of data....
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