Article
Evolution of drug resistance during 48 weeks of zidovudine/lamivudine/tenofovir in the absence of real-time viral load monitoring.
Journal of acquired immune deficiency syndromes (1999) - 1 Oct 2010
Lyagoba Fred, Dunn David T, Pillay Deenan, Kityo Cissy, Robertson Val, Tugume Stephano, Hakim James, Munderi Paula, Chirara Mike, Ndembi Nicaise, Goodall Ruth L, Yirrell David L, Burke Andy, Gilks Charles F, Kaleebu Pontiano
Abstract excerpt
OBJECTIVES: To describe the resistance mutations selected by a first-line regimen of zidovudine/lamivudine/tenofovir in the absence of real-time viral load monitoring. DESIGN: A substudy of 300 participants from the Development of Antiretroviral Therapy in Africa trial in Uganda and Zimbabwe, which compared managing antiretroviral therapy with and without laboratory monitoring. METHODS: Stored plasma samples from...
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