Article
Virologic versus immunologic monitoring and the rate of accumulated genotypic resistance to first-line antiretroviral drugs in Uganda.
BMC infectious diseases - 27 Dec 2012
Reynolds Steven J, Sendagire Hakim, Newell Kevin, Castelnuovo Barbara, Nankya Immaculate, Kamya Moses, Quinn Thomas C, Manabe Yukari C, Kambugu Andrew
Abstract excerpt
BACKGROUND: Viral load monitoring (VLM) to identify individuals failing antiretroviral therapy (ART) is not widely available in resource-limited settings. We compared the genotypic resistance patterns between clients with VLM versus immunological monitoring (IM). METHODS: Between 2004-2008, 559 ART naïve clients were enrolled in a prospective cohort, initiated on ART, and monitored with viral load (VL) and CD4+...
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