Article
Genotypic resistance at viral rebound among patients who received lopinavir/ritonavir-based or efavirenz-based first antiretroviral therapy in South Africa.
Journal of acquired immune deficiency syndromes (1999) - 1 Nov 2011
Dlamini J Nomthandazo, Hu Zonghui, Ledwaba Johanna, Morris Lynn, Maldarelli Frank M, Dewar Robin L, Highbarger Helene C, Somaroo Harsha, Sangweni Phumelele, Follmann Dean A, Pau Alice K
Abstract excerpt
Nonnucleoside reverse transcriptase inhibitor-drug resistance mutations (DRM) are increasingly reported in Africans failing their first antiretroviral regimen. The Phidisa II trial randomized treatment-naive participants to lopinavir/ritonavir or efavirenz with stavudine + lamivudine or zidovudine + didanosine. We report the prevalence of DRM in subjects who achieved HIV RNA <400 copies per milliliter at 6...
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