Viral rebound and emergence of drug resistance in the absence of viral load testing: a randomized comparison between zidovudine-lamivudine plus Nevirapine and zidovudine-lamivudine plus Abacavir.

doi:10.1086/648590

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Article

Viral rebound and emergence of drug resistance in the absence of viral load testing: a randomized comparison between zidovudine-lamivudine plus Nevirapine and zidovudine-lamivudine plus Abacavir.

The Journal of infectious diseases - 1 Jan 2010

Ndembi Nicaise, Ndembi Nicasie, Goodall Ruth L, Dunn David T, McCormick Adele, Burke Andy, Lyagoba Fred, Munderi Paula, Katundu Pauline, Kityo Cissy, Robertson Val, Yirrell David L, Walker A Sarah, Gibb Diane M, Gilks Charles F, Kaleebu Pontiano, Pillay Deenan

Abstract excerpt

BACKGROUND: We investigated virological response and the emergence of resistance in the Nevirapine or Abacavir (NORA) substudy of the Development of Antiretroviral Treatment in Africa (DART) trial. METHODS: Six hundred symptomatic antiretroviral-naive human immunodeficiency virus (HIV)-infected adults (CD4 cell count, <200 cells/mm(3)) from 2 Ugandan centers were randomized to receive zidovudine-lamivudine plus...

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PMID: 19938977
DOI: 10.1086/648590

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