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Article

Herpes virus proteins ICP0 and BICP0 can activate NF-kappaB by catalyzing IkappaBalpha ubiquitination.

Cellular signalling - 1 Feb 2005

Diao Lirong, Zhang Bianhong, Fan Junkai, Gao Xiang, Sun Shaogang, Yang Kai, Xin Dan, Jin Naihe, Geng Yunqi, Wang Chen

Abstract excerpt

The immediate early proteins ICP0 and BICP0 from Herpes virus are promiscuous activators of both viral and cellular genes and play a critical role in virus life cycle. Here we report that ICP0 and BICP0 could induce NF-kappaB translocation from cytoplasm into nucleus and strongly activate NF-kappaB responsive genes specifically. This process was dependent on the RING domain of both proteins. In addition, ICP0...

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Identifiers

PMID: 15494213
DOI: 10.1016/j.cellsig.2004.07.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Herpes virus proteins ICP0 and BICP0 can activate NF-kappaB by catalyzing IkappaBalpha ubiquitination.PMID 15494213Read ↗

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