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Article

Conformation of the mineralocorticoid receptor N-terminal domain: evidence for induced and stable structure.

Molecular endocrinology (Baltimore, Md.) - 1 Oct 2010

Fischer Katharina, Kelly Sharon M, Watt Kate, Price Nicholas C, McEwan Iain J

Abstract excerpt

The mineralocorticoid receptor (MR) binds the steroid hormones aldosterone and cortisol and has an important physiological role in the control of salt homeostasis. Regions of the protein important for gene regulation have been mapped to the amino-terminal domain (NTD) and termed activation function (AF)1a, AF1b, and middle domain (MD). In the present study, we used a combination of biophysical and biochemical...

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Identifiers

PMID: 20685853
DOI: 10.1210/me.2010-0005
PMCID: PMC5417395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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