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Article

Incorrect DNA methylation of the DAZL promoter CpG island associates with defective human sperm†

4 Aug 2010

Abstract excerpt

BACKGROUND: Successful gametogenesis requires the establishment of an appropriate epigenetic state in developing germ cells. Nevertheless, an association between abnormal spermatogenesis and epigenetic disturbances in germline-specific genes remains to be demonstrated. METHODS: In this study, the DNA methylation pattern of the promoter CpG island (CGI) of two germline regulator genes--DAZL and DAZ, was...

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Share to Epigenetics and DNA Methylation
Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Sperm and Testicular Function

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PMID: 20685756
DOI: 10.1093/humrep/deq200

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