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Article

Altered DNA methylation patterns of the H19 differentially methylated region and the DAZL gene promoter are associated with defective human sperm.

PloS one - 1 Jan 2013

Li Bo, Li Jian-bo, Xiao Xi-feng, Ma Ye-fei, Wang Jun, Liang Xin-xin, Zhao Hong-xi, Jiang Feng, Yao Yuan-qing, Wang Xiao-hong

Abstract excerpt

DNA methylation disturbance is associated with defective human sperm. However, oligozoospermia (OZ) and asthenozoospermia (AZ) usually present together, and the relationship between the single-phenotype defects in human sperm and DNA methylation is poorly understood. In this study, 20 infertile OZ patients and 20 infertile AZ patients were compared with 20 fertile normozoospermic men. Bisulfate-specific PCR was...

Read the complete abstract on PubMed

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Share to Asthenozoospermia
Share to Comparative Genomic Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Oligospermia

Share to RNA-Binding Proteins

Share to RNA, Long Noncoding

Source

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Identifiers

PMID: 24015185
DOI: 10.1371/journal.pone.0071215
PMCID: PMC3756053

Genes

DAZL
CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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