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Promoter targeted bisulfite sequencing reveals DNA methylation profiles associated with low sperm motility in asthenozoospermia

30 Nov 2015

Abstract excerpt

STUDY QUESTION: Is there an association between sperm DNA methylation profiles and asthenozoospermia? SUMMARY ANSWER: DNA methylation, at specific CpGs but not at the global level, was significantly different between low motile sperm cells of asthenozoospermic individuals and high motile sperm cells of normozoospermic controls. WHAT IS KNOWN ALREADY: Aberrant DNA methylation, both globally and restricted to a...

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PMID: 26628640
DOI: 10.1093/humrep/dev283

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